An existing constipation drug could help clear the brain fog that often lingers after depression, according to a small clinical trial published in Psychological Medicine. Researchers from the University of Birmingham and the University of Oxford found that people with a history of depression who took prucalopride for about a week performed better on tests of memory, attention, and thinking speed than those who received a placebo.
The research
Dr. Angharad de Cates of the University of Birmingham led the study, which enrolled 50 adults who had recovered from depression at least six months prior and were not taking medication. Participants received either 2 mg of prucalopride—the standard dose for chronic constipation—or a placebo for 7 to 10 days. Before and after treatment, they completed cognitive tests measuring memory, executive function, and emotional processing.
Those taking prucalopride achieved higher accuracy (z=+0.59) and faster response times (z=-0.69) compared to the placebo group. The drug works by activating the serotonin 5-HT4 receptor, found in both the gut and the brain. No significant side effects were reported, likely because the laxative effect was mild at this dose.
Why it matters
Cognitive problems like poor concentration, memory lapses, and mental slowness are common in depression and can persist even when mood improves. These symptoms are often overlooked but can significantly impact daily life and work performance. This study provides early evidence that targeting the 5-HT4 receptor could offer a new way to improve cognitive function in people with a history of depression, potentially opening the door to repurposing existing drugs.
What you can do
If you experience persistent brain fog during or after depression, talk to your doctor about current treatment options. While prucalopride is not yet approved for this use, this research highlights the importance of cognitive health. You can also support your brain with regular exercise, adequate sleep, and a balanced diet. For a baseline measure of your cognitive abilities, consider taking a validated test.
Source: ScienceDaily Mind & Brain
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